Testicular Sertoli cell function in male systemic lupus erythematosus
Identifieur interne : 001936 ( Main/Exploration ); précédent : 001935; suivant : 001937Testicular Sertoli cell function in male systemic lupus erythematosus
Auteurs : R. M. Suehiro [Brésil] ; E. F. Borba [Brésil] ; E. Bonfa [Brésil] ; T. S. Okay [Brésil] ; M. Cocuzza [Brésil] ; P. M. F. Soares [Brésil] ; C. A. A. Silva [Brésil]Source :
- Rheumatology [ 1462-0324 ] ; 2008.
Abstract
Objective. To assess the testicular Sertoli cell function in male SLE patients. Methods. Thirty-four consecutive patients were prospectively selected to evaluate serum inhibin B. Clinical features, treatment, semen analysis, urological evaluation, testicular ultrasound, hormones and anti-sperm antibodies were determined. Results. Patients were subdivided into two groups: low serum inhibin B (Group 1, n = 8) and normal levels (Group 2, n = 26). The median sperm concentration (P = 0.024), total sperm count (P = 0.023) and total motile sperm count (P = 0.025) were lower in Group 1. Inhibin B levels were positively correlated with sperm concentration (r = 0.343), total motile sperm count (r = 0.357), and negatively correlated with follicule-stimulating hormone (FSH) (r = 0.699) and luteinizing hormone (r = 0.397). The median serum inhibin B was lower in SLE patients treated with intravenous cyclophosphamide (IVCYC) compared with those without this therapy (P = 0.031). Further evaluation of the 26 SLE patients with normal inhibin B and FSH levels revealed that medians of inhibin B/FSH ratio were lower in SLE patients with oligozoospermia compared with normozoospermia (P = 0.004). This ratio was also lower in SLE patients treated with IVCYC than those without this therapy (P = 0.04). In contrast, inhibin B serum level alone did not discriminate the later group of patients (P = 0.12). Conclusions. This is the first study to identify a high frequency of testicular Sertoli cell dysfunction in male SLE associated with semen abnormalities. Further prospective studies are necessary to determine if inhibin levels and inhibin B/FSH ratio will be an earlier and useful marker of IVCYC toxicity in these patients.
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DOI: 10.1093/rheumatology/ken338
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M." last="Suehiro">R. M. Suehiro</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Rheumatology, Pediatric Laboratory, Division of Urology and Pediatric Rheumatology Unit, Department of Pediatrics, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Borba, E F" sort="Borba, E F" uniqKey="Borba E" first="E. F." last="Borba">E. F. 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Bonfa</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Rheumatology, Pediatric Laboratory, Division of Urology and Pediatric Rheumatology Unit, Department of Pediatrics, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Okay, T S" sort="Okay, T S" uniqKey="Okay T" first="T. S." last="Okay">T. S. 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Cocuzza</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Rheumatology, Pediatric Laboratory, Division of Urology and Pediatric Rheumatology Unit, Department of Pediatrics, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Soares, P M F" sort="Soares, P M F" uniqKey="Soares P" first="P. M. F." last="Soares">P. M. F. Soares</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Rheumatology, Pediatric Laboratory, Division of Urology and Pediatric Rheumatology Unit, Department of Pediatrics, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Silva, C A A" sort="Silva, C A A" uniqKey="Silva C" first="C. A. A." last="Silva">C. A. A. Silva</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Rheumatology, Pediatric Laboratory, Division of Urology and Pediatric Rheumatology Unit, Department of Pediatrics, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Brésil</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Rheumatology</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><publisher>Oxford University Press</publisher><date when="2008-11">2008</date><date type="e-published" when="2008-09-11">2008</date><biblScope unit="vol">47</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1692">1692</biblScope><biblScope unit="page" to="1697">1697</biblScope></imprint><idno type="ISSN">1462-0324</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-0324</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Objective. To assess the testicular Sertoli cell function in male SLE patients. Methods. Thirty-four consecutive patients were prospectively selected to evaluate serum inhibin B. Clinical features, treatment, semen analysis, urological evaluation, testicular ultrasound, hormones and anti-sperm antibodies were determined. Results. Patients were subdivided into two groups: low serum inhibin B (Group 1, n = 8) and normal levels (Group 2, n = 26). The median sperm concentration (P = 0.024), total sperm count (P = 0.023) and total motile sperm count (P = 0.025) were lower in Group 1. Inhibin B levels were positively correlated with sperm concentration (r = 0.343), total motile sperm count (r = 0.357), and negatively correlated with follicule-stimulating hormone (FSH) (r = 0.699) and luteinizing hormone (r = 0.397). The median serum inhibin B was lower in SLE patients treated with intravenous cyclophosphamide (IVCYC) compared with those without this therapy (P = 0.031). Further evaluation of the 26 SLE patients with normal inhibin B and FSH levels revealed that medians of inhibin B/FSH ratio were lower in SLE patients with oligozoospermia compared with normozoospermia (P = 0.004). This ratio was also lower in SLE patients treated with IVCYC than those without this therapy (P = 0.04). In contrast, inhibin B serum level alone did not discriminate the later group of patients (P = 0.12). Conclusions. This is the first study to identify a high frequency of testicular Sertoli cell dysfunction in male SLE associated with semen abnormalities. Further prospective studies are necessary to determine if inhibin levels and inhibin B/FSH ratio will be an earlier and useful marker of IVCYC toxicity in these patients.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Suehiro, R M" sort="Suehiro, R M" uniqKey="Suehiro R" first="R. M." last="Suehiro">R. M. Suehiro</name></region><name sortKey="Bonfa, E" sort="Bonfa, E" uniqKey="Bonfa E" first="E." last="Bonfa">E. Bonfa</name><name sortKey="Borba, E F" sort="Borba, E F" uniqKey="Borba E" first="E. F." last="Borba">E. F. Borba</name><name sortKey="Cocuzza, M" sort="Cocuzza, M" uniqKey="Cocuzza M" first="M." last="Cocuzza">M. Cocuzza</name><name sortKey="Okay, T S" sort="Okay, T S" uniqKey="Okay T" first="T. S." last="Okay">T. S. Okay</name><name sortKey="Silva, C A A" sort="Silva, C A A" uniqKey="Silva C" first="C. A. A." last="Silva">C. A. A. Silva</name><name sortKey="Silva, C A A" sort="Silva, C A A" uniqKey="Silva C" first="C. A. A." last="Silva">C. A. A. Silva</name><name sortKey="Soares, P M F" sort="Soares, P M F" uniqKey="Soares P" first="P. M. F." last="Soares">P. M. F. Soares</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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